Сравнительная оценка эффективности действия препаратов линейки Aquashine на фибробласты кожи при старении in vitro (клеточно-молекулярное исследование).

В.О. Полякова, З.И. Газитаева, Т.С. Клейменова, А.О. Дробинцева, И.М. Кветной

Research output: Contribution to journalArticle


Introduction. Skin aging is a natural process that cannot be stopped. However, there are many ways to help stop premature aging of the skin and reduce the signs that have already appeared. One of them is the subcutaneous administration of preparations containing biomimetic peptides capable of interacting with growth factor receptors and providing an anti-aging clinical effect. The purpose of this study was to compare the geroprotective properties of the preparations Aquashine and Aquashine HA. Methods. To study the aging of skin fibroblasts in culture, the cell culture method was used, and immunocytochemistry and confocal microscopy were used to identify markers of aging. Results. The preparation Aquashine HA has the ability to activate proliferative processes in the skin, and, by virtue of its properties, regulates the processes of cell renewal through increased cell apoptosis. Conclusion. Aquashine HA has a more pronounced geroprotective effect compared to Aquashine.
Original languageRussian
Pages (from-to)37-42
Issue number3
StatePublished - 2019
Externally publishedYes


  • biomimetic peptides
  • collagen
  • reparative processes
  • sirtuin-1
  • skin aging
  • биомиметические пептиды
  • коллаген
  • репаративные процессы
  • сиртуин-1
  • старение кожи

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