Comparison of pheochromocytoma-specific mobidity and mortality among adults with bilateral pheochromocytomas undergoing total adrenalectomy versus cortical-sparing adrenalectomy

Research output

Abstract

Question: What is the best clinical workup and surgical management of a patient with bilateral pheochromocytoma?
Findings: In this international multi-center cohort study, 625 patients with bilateral pheochromocytomas were usually diagnosed with a hereditary syndrome, but 36% of the time initially presented with unilateral pheochromocytoma. Bilateral total adrenalectomy resulted in a high rate of side effects from glucocorticoid replacement therapy, whereas cortical-sparing surgery was not associated with a worse outcome.
Meaning: Cortical-sparing surgery is the preferred approach for patients at risk for, or diagnosed with bilateral pheochromocytomas, especially those harboring a germline mutation in one of the known predisposition genes.
Original languageEnglish
JournalJAMA Internal Medicine
Publication statusAccepted/In press - 10 Apr 2019

Cite this

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title = "Comparison of pheochromocytoma-specific mobidity and mortality among adults with bilateral pheochromocytomas undergoing total adrenalectomy versus cortical-sparing adrenalectomy",
abstract = "Question: What is the best clinical workup and surgical management of a patient with bilateral pheochromocytoma?Findings: In this international multi-center cohort study, 625 patients with bilateral pheochromocytomas were usually diagnosed with a hereditary syndrome, but 36{\%} of the time initially presented with unilateral pheochromocytoma. Bilateral total adrenalectomy resulted in a high rate of side effects from glucocorticoid replacement therapy, whereas cortical-sparing surgery was not associated with a worse outcome.Meaning: Cortical-sparing surgery is the preferred approach for patients at risk for, or diagnosed with bilateral pheochromocytomas, especially those harboring a germline mutation in one of the known predisposition genes.",
author = "Худякова, {Наталья Валерьевна}",
year = "2019",
month = "4",
day = "10",
language = "English",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",

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AU - Худякова, Наталья Валерьевна

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Y1 - 2019/4/10

N2 - Question: What is the best clinical workup and surgical management of a patient with bilateral pheochromocytoma?Findings: In this international multi-center cohort study, 625 patients with bilateral pheochromocytomas were usually diagnosed with a hereditary syndrome, but 36% of the time initially presented with unilateral pheochromocytoma. Bilateral total adrenalectomy resulted in a high rate of side effects from glucocorticoid replacement therapy, whereas cortical-sparing surgery was not associated with a worse outcome.Meaning: Cortical-sparing surgery is the preferred approach for patients at risk for, or diagnosed with bilateral pheochromocytomas, especially those harboring a germline mutation in one of the known predisposition genes.

AB - Question: What is the best clinical workup and surgical management of a patient with bilateral pheochromocytoma?Findings: In this international multi-center cohort study, 625 patients with bilateral pheochromocytomas were usually diagnosed with a hereditary syndrome, but 36% of the time initially presented with unilateral pheochromocytoma. Bilateral total adrenalectomy resulted in a high rate of side effects from glucocorticoid replacement therapy, whereas cortical-sparing surgery was not associated with a worse outcome.Meaning: Cortical-sparing surgery is the preferred approach for patients at risk for, or diagnosed with bilateral pheochromocytomas, especially those harboring a germline mutation in one of the known predisposition genes.

M3 - Article

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

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