Синтез и биологическая активность 5-арил-n-{4-[(1,3-тиазол-2-ил)cульфамоил]фенил}1-фенилпиразол-3-карбоксамидов и их солей.

А.А. Русских, В.Л. Гейн, О.В. Бобровская, В.В. Новикова, О.Н. Гейн, Ю.Н. Карпенко, С.В. Чащина, М.В. Дмитриев, А.Н. Янкин

Research output: Contribution to journalArticle

Abstract

Reaction of 4-aryl-2-hydroxy-4-oxo- N -{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl- N -{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenylpyrazole-3carboxamides, which were converted into silver salts when treated with an equimolar amount of silver nitrate in ethanol-DMF (2:1). 5-Aryl- N -{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenylpyrazole-3-carboxamides sodium salts were synthesized by reacting with sodium methoxide methanol-DMF (1:1). Analgesic, anti-inflammatory and antimicrobial activity of the compounds obtained was studied.
Original languageRussian
Pages (from-to)542-551
JournalЖУРНАЛ ОБЩЕЙ ХИМИИ
Volume89
Issue number4
StatePublished - 2019
Externally publishedYes

Keywords

  • analgesic activity
  • anti-inflammatory activity
  • antimicrobial activity
  • pyrazole-3-carboxamides
  • silver and sodium salts of pyrazole-3-carboxamides
  • анальгетическая активность
  • пиразол-3-карбоксамиды
  • противовоспалительная активность
  • противомикробная активность
  • серебряные и натриевые соли пиразол-3-карбоксамидов

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