Прогностическая роль показателей системы матриксные металлопротеиназы/ингибиторы в оценке характера репаративных изменений легочной ткани при инфильтративном туберкулезе легких.

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2 Citations (Scopus)
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Abstract

The objective: to study the rates of matrix metalloproteinases/inhibitors system in infiltrate pulmonary tuberculosis during changes occurring
in the intensive phase of treatment in order to develop a statistic model aimed to predict reparative changes.
Subjects and methods. The test of ELISA (Bender MedSystems, USA) was used to measure the levels of MMP-1, MMP-8,-9. TIMM and
α2
-macroglobulin in blood serum of 35 patients with verified infiltrate pulmonary tuberculosis and various reparative changes during the intensive
phase of treatment. The extension of infiltrative changes in the lung tissue was calculated (Vitrea, Nodule Analysis). The software of Statistica 10,
ANOVA Repeated Measures and multiple discriminant analysis were used.
Results. Infiltrate pulmonary tuberculosis disrupts the balance in MMP/inhibitors system regardless of the character of reparative changes: MMP-9
goes higher and the reference level of TIMM-1 and α2
-macroglobulin persists. The level of MMP-9 significantly goes down but does not become
normal in all variants of the disease involution. Persisting high levels of MMP-8 reduces the chances of cavity healing, while the increasing level
of MMP-1 promotes resolution of cavities. To predict the character of reparative changes upon the completion of the intensive phase of treatment
of infiltrate pulmonary tuberculosis, the combination of levels of MMP/inhibitors with lung tissue changes during the intensive phase of treatment
is the most informative.
Key words: tuberculosis, matrix metalloproteinases, metalloproteinase inhibitors, reparation
Translated title of the contributionTHE PREDICTIVE FUNCTION OF RATES OF MATRIX METALLOPROTEINASES/INHIBITORS SYSTEM WHEN ASSESSING REPARATIVE CHANGES IN THE LUNG TISSUE IN THOSE WITH INFILTRATE PULMONARY TUBERCULOSIS
Original languageRussian
Pages (from-to)38-44
Number of pages7
JournalТУБЕРКУЛЕЗ И БОЛЕЗНИ ЛЕГКИХ
Volume96
Issue number9
DOIs
Publication statusPublished - 2018

Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Pulmonary and Respiratory Medicine

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