Полиморфизм генов TOLL-подобных рецепторов и ассоциированные с ним заболевания.

К.А. Дворникова, Е.Ю. Быстрова, О.Н. Платонова, А.Д. Ноздрачев

Research output: Contribution to journalArticle


Introduction. In recent years, there have been aroused and actively studied mutations associated with Toll-like receptor genes (TLRs). The emerging interest is related to the identification of many associations between the TLRs polymorphism and the development of pathological conditions. Single nucleotide polymorphism (SNP) is a variant of point mutation. If two sequences in DNA differ by one nucleotide, then two alleles appear. As a result of single nucleotide polymorphisms in TLRs, the functioning of some key signaling pathways is impaired which in turn increases the risk of developing autoimmune, oncological and cardiovascular diseases. The aim of the study. The present study is devoted both to examining the current state of the problem, and, in particular, summarizing the information presented in the literature about the role of TLRs polymorphism in the occurrence of a number of diseases of the digestive system. Results. The analysis of studies on the nature of SNPs and their role in the body allowed esta
Original languageRussian
Pages (from-to)5-12
Issue number6
StatePublished - 2019
Externally publishedYes


  • carcinogenesis
  • digestive system
  • gene polymorphism
  • mutations
  • single nucleotide polymorphism (SNP)
  • Toll-like receptors (TLRs)
  • Toll-подобные рецепторы (TLRs)
  • канцерогенез
  • мутации
  • однонуклеотидный полиморфизм (SNP)
  • пищеварительная система
  • полиморфизм генов

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