Обзор механизмов действия цитокина Tgfβ3 как терапевтического агента для увеличения синтеза внеклеточного матрикса гиалинового хряща.

Ю.В. Сопова, М.С. Божокин, Д.В. Качкин, М.Г. Хотин

Research output: Contribution to journalArticle

Abstract

Hyaline cartilage is forming a nonvascular connective tissue of the joints surface, consisting mostly from extracellular matrix proteins and a small number of highly differentiated chondrocytes cells. Nowadays are investigated a various techniques for repairing a joint surfaces damages, for example, the using of modified cell culture and biodegradable scaffolds. Molecular mechanisms of cartilage tissue proliferation are being actively studied during recent years. One of the most important proteins among cytokines and growth factors affecting the chondrogenesis is Tgfβ3, which plays a critical role in normal cartilage tissue proliferation. Via direct interaction with ligands on the surface of cell membrane, Tgfβ3 triggers a cascade of molecular interactions involving transcription factor Sox9. In this review we study the effect of Tgfβ3 on the receptor complex activation and subsequent intracellular movement of the associated Smad mediators. An analysis and the relation of these processes and a major extracell
Original languageRussian
Pages (from-to)507-520
JournalБИОХИМИЯ
Volume85
Issue number4
StatePublished - 2020
Externally publishedYes

Keywords

  • extracellular matrix
  • hyaline cartilage
  • mechanism of action
  • SMAD proteins
  • Smad белки
  • TGF-β3
  • внеклеточный матрикс
  • гиалиновый хрящ
  • механизм действия

Cite this