Neurogenic and septic inductions of synthesis of peptide antibiotics in larvae of Calliphora vicina R.-D. (Diptera: Calliphoridae)

N. A. Gordya, A. N. Nesin, N. P. Simonenko, A. Yu Yakovlev, S. I. Chernysh

Research output: Contribution to journalArticlepeer-review

Abstract

Synthesis of antimicrobial peptides in diapausing larvae of the blowfly Calliphora vicina can be induced by two different pathways. One pathway is well known in insects and includes recognition of microbial particles by the pattern-recognizing receptors. The other pathway includes perception and transduction of stress signal to immunocompetent cells by neuroendocrine system. This phenomenon consists in stimulation of synthesis of defensins, cecropins, and diptericins under effect of chromic stimulation of mechanoreceptors with ligature applied on the larva head end. Formation of immune response in brain is established to need less than 30 s, after which isolation of the neuroendocrine complex does not eliminate activation of immune response. As judging from rate of the neurogenic induction, transduction of the stimulating signal from brain to the immune system cells can be connected with release into hemolymph of biogenic amines or other neurohormones stored preliminarily in the neurohemal organ. The nature of this inductor at present remains unknown, as analysis of role of octopamine, dopamine, and adipokinetic hormone did not reveal stimulating effect on synthesis of bactericidal peptides. Physiological mechanism of this phenomenon is not finally understood, its key links seem to be CNS, hormonal factor of cardiac bodies, and system of antimicrobial peptides. Synthesis of antimicrobial peptides is directly regulated by the neuroendocrine system that can produce both stimulating and stress action by reminding in this aspect the known immunoneuroendocrine interrelations in vertebrates. The existence of similar integrating mechanisms in such polar animal kingdom groups as insects and vertebrates indicate that they are more ancient than this was considered earlier.

Translated title of the contributionНейрогенная и септическая индукция синтеза пептидных антибиотиков у личинок мухи Calliphora vicina R.-D. (Diptera, Calliphoridae)
Original languageEnglish
Pages (from-to)196-203
Number of pages8
JournalJournal of Evolutionary Biochemistry and Physiology
Volume47
Issue number2
DOIs
StatePublished - 1 Apr 2011

Scopus subject areas

  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry

Keywords

  • antimicrobial peptides
  • Calliphora vicina
  • immune and neuroendocrine systems
  • insects
  • stress

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