клонидина и дексмедетомидина для профилактики нейрокогнитивных нарушений в ближайшем послеоперационном периоде после аортокоронарного шунтирования

Translated title of the contribution: Intraoperative use of clonidine and dexmedetomidine for prevention of early postoperative neurocognitive disorders after coronary artery bypass surgery

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To evaluate an effectiveness of intraoperative use of dexmedetomidine and clonidine for prevention of early postoperative neurocognitive disorders after coronary artery bypass grafting. Material and methods. A prospective study included 200 patients who underwent elective coronary artery bypass grafting under general combined anesthesia for the period from 2018 to 2019. Patients were randomized into 3 groups: group 1 (control) — 100 pa-tients, group 2 (clonidine) — 50 patients, and group 3 (dexmedetomidine) — 50 patients. Inclusion criteria were elective coronary artery bypass grafting, age 40—80 years, LV ejection fraction (Simpson’s method) >50%, absence of dementia and mental illness. Clonidine and dexmedetomidine were injected after anesthesia induction and for 2 hours in early postoperative period. PND were evaluated using NuDESC (Nursing delirium screening scale) and SAGE (Self-Administrated Gerocognitive Exam) scales. Results. In the control group, delirium developed in 19% of patients, in clonidine group — 6%, dexmedetomidine group — 4% of patients (p=0,010 compared to the control group). Conclusion. Intraoperative use of clonidine and dexmedetomidine reduced the incidence of delirium in postoperative period.

Translated title of the contributionIntraoperative use of clonidine and dexmedetomidine for prevention of early postoperative neurocognitive disorders after coronary artery bypass surgery
Original languageRussian
Pages (from-to)42-47
Number of pages6
JournalRussian Journal of Anesthesiology and Reanimatology
Volume2020
Issue number4
DOIs
StatePublished - 2020

Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Emergency Medicine

Keywords

  • Alpha-2 adrenergic receptor agonists
  • Clonidine
  • Coronary artery bypass grafting
  • Dexmedetomidine
  • Postoperative neurocognitive dysfunction

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