A Study of the Association between Breastfeeding and DNA Methylation in Peripheral Blood Cells of Infants

O. Yu Naumova, V. V. Odintsova, I. A. Arincina, S. Yu Rychkov, R. J. Muhamedrahimov, Yu V. Shneider, A. N. Grosheva, O. V. Zhukova, E. L. Grigorenko

Research output

Abstract

This article reports on new data on the association of breastfeeding with DNA methylation in the peripheral blood cells of 37 children aged from 9 months to four years. Whole-genome DNA methylation profiling was performed using the Illumina Methylation EPIC array. The Epigenome-Wide Association Study (EWAS) revealed an association between the duration of breastfeeding and the methylation level of 4276 CpG sites related to 2635 genes. According to the functional annotation, these genes were predominantly involved in the control of cell signaling systems, the development of anatomical structures and cells, and, above all, were related to the development and function of the immune system and the CNS. The results of the study allowed assuming a special role of the oxytocin signaling pathway, as a potential trigger of coordinated epigenetic changes in the genes involved in the CNS function in response to breastfeeding.

Original languageEnglish
Pages (from-to)749-755
Number of pages7
JournalRussian Journal of Genetics
Volume55
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

Fingerprint

DNA Methylation
Breast Feeding
Blood Cells
Methylation
Molecular Sequence Annotation
DNA Fingerprinting
Oxytocin
Epigenomics
Genes
Immune System
Genome

Scopus subject areas

  • Genetics

Cite this

Naumova, O. Yu ; Odintsova, V. V. ; Arincina, I. A. ; Rychkov, S. Yu ; Muhamedrahimov, R. J. ; Shneider, Yu V. ; Grosheva, A. N. ; Zhukova, O. V. ; Grigorenko, E. L. / A Study of the Association between Breastfeeding and DNA Methylation in Peripheral Blood Cells of Infants. In: Russian Journal of Genetics. 2019 ; Vol. 55, No. 6. pp. 749-755.
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A Study of the Association between Breastfeeding and DNA Methylation in Peripheral Blood Cells of Infants. / Naumova, O. Yu; Odintsova, V. V.; Arincina, I. A.; Rychkov, S. Yu; Muhamedrahimov, R. J.; Shneider, Yu V.; Grosheva, A. N.; Zhukova, O. V.; Grigorenko, E. L.

In: Russian Journal of Genetics, Vol. 55, No. 6, 01.06.2019, p. 749-755.

Research output

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AU - Arincina, I. A.

AU - Rychkov, S. Yu

AU - Muhamedrahimov, R. J.

AU - Shneider, Yu V.

AU - Grosheva, A. N.

AU - Zhukova, O. V.

AU - Grigorenko, E. L.

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