Использование рекомбинантного белка Vp2 в качестве субъединичной вакцины против инфекционной бурсальной болезни

Translated title of the contribution: THE USE OF RECOMBINANT PROTEIN VP2 AS A SUB-UNIT VACCINE AGAINST INFECTIOUS BURSAL DISEASE

Эдуард Джавадов, Андрей Михайлович Румянцев, Владислав Веретенников, Николай Тарлавин

Research output: Contribution to journalArticlepeer-review

Abstract

In all poultry producing regions of the world, infectious bursal disease (IBD) virus continues to be a major concern for poultry farmers. The virus causes anemic and dehydrated muscle tissue in chickens, as well as hemorrhages in the muscles of the lower leg, thigh, wings and chest. The most characteristic of this disease are observed in the fabrication bursa. In the first 2-4 days after infection of the bird, it increases 2-3 times. Its mucous membrane becomes edematous, hyperemic, hemorrhages and necrotic areas are found in it. The mortality from this disease is low, but the main danger of IBD is the immunosuppressive state it causes. The consequences of immunosuppression associated with IBD, an increase in the susceptibility of chickens to opportunistic microorganisms, an increase in susceptibility to diseases and a decrease in the effectiveness of vaccination against Newcastle disease, Marek's disease, infectious bronchitis, etc. Vaccination is the most important measure for combating IBD in the field. Today, live and inactivated vaccines against infectious bursal disease are widely used in poultry farms. A large number of disadvantages of their use have been found, therefore, the relevance of recombinant vaccines based on the viral VP2 p rotein has increased, which are considered safer and cheaper. Vaccinated chickens, in which the synthesis of virus-neutralizing antibodies to the VP2 capsid protein occurs, are resistant to infectious bursal disease. The aim of the work was the recombinant protein VP2 and to test its effectiveness in chickens of the Lohman Brown cross.
Translated title of the contributionTHE USE OF RECOMBINANT PROTEIN VP2 AS A SUB-UNIT VACCINE AGAINST INFECTIOUS BURSAL DISEASE
Original languageRussian
Pages (from-to)9-14
JournalМеждународный вестник ветеринарии
Issue number3
StatePublished - 2021

Fingerprint

Dive into the research topics of 'THE USE OF RECOMBINANT PROTEIN VP2 AS A SUB-UNIT VACCINE AGAINST INFECTIOUS BURSAL DISEASE'. Together they form a unique fingerprint.

Cite this