Ингибиторы натрий-глюкозного ко-транспортера 2-го типа: успешная погоня за двумя зайцами

Translated title of the contribution: Sodium-glucose cotransporter type 2 inhibitors: Successful running after two hares

Research output: Contribution to journalArticlepeer-review

Abstract

The review is devoted to the clinical efficacy of sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Information on the mechanisms of drug action is given, as well as rationale for their use in the management of patients with diabetes and heart failure (HF) is provided. The results of large-scale randomized clinical trials evaluating the efficacy of SGLT2 inhibitors are discussed. We showed the beneficial effect of SGLT-2 inhibitors on the risk of cardiovascular events in patients with type 2 diabetes. In addition, an evidence of the ability of dapagliflozin and empagliflozin to improve the prognosis of patients with HF with reduced ejection fraction without diabetes are presented. The evidence and mechanisms of the nephroprotective action of SGLT2 inhibitors in patients with diabetes and HF are considered.

Translated title of the contributionSodium-glucose cotransporter type 2 inhibitors: Successful running after two hares
Original languageRussian
Pages (from-to)54-62
Number of pages9
Journal РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ ЖУРНАЛ
Volume26
Issue numberS2
DOIs
StatePublished - 2021

Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Keywords

  • Diabetes
  • Heart failure
  • Prognosis
  • Sodium-glucose cotransporter type 2 inhibitors

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