Заместительная уретропластика тканеинженерными конструкциями в эксперименте

Translated title of the contribution: SUBSTITUTIONAL URETHROPLASTY WITH TISSUE-ENGINEERED STRUCTURES IN AN EXPERIMENT

Анна Андреевна Горелова, Александр Николаевич Муравьев, Татьяна Ивановна Виноградова, Андрей Игоревич Горелов, Наталья Михайловна Юдинцева, Юлия Александровна Нащекина, Игорь Алексеевич Самусенко, Петр Казимирович Яблонский

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. In order to exclude the difficulties arising in the course of traditional surgical interventions in the scope of substitutional urethroplasty, in recent years, alternative materials have been developed using tissue engineering. This study is devoted to the development of new tissue-engineered constructions for urethroplasty using cells of different tissue origins and biopolymers, which is an urgent problem of modern medicine. Aim. Experimental provision of a rationale for the possibility of using tissue-engineered constructions to replace urethral defects. Methods and materials. Two-staged, experimental, controlled study. Dedicated to the development of tissue-engineered constructions (TEC) based on biopolymers seeded with mesenchymal stem cells or buccal epithelial cells. The prepared TECs were implanted into the rabbit’s urethra wall in a acute trauma model. Comparison of the results of the TECs usage with the “gold standard” - buccal urethraplasty was carried out. Results. Urethrography showed similar results in all groups of animals, regardless the type of implanted material. No urethral patency was found, and confocal microscopy of urethral cryosections revealed the presence of nanoparticle-labeled mesenchymal stem cells / buccal epithelium cells with signs of their differentiation in the urothelial direction in the mucous layer. Conclusion. The possibility of using tissue-engineered constructions based on biopolymers containing autologous mesenchymal stem cells or buccal epithelium cells for experimental substitutional urethroplasty was shown. The developed TECs can be used as an alternative to buccal urethroplasty in an experiment.
Translated title of the contributionSUBSTITUTIONAL URETHROPLASTY WITH TISSUE-ENGINEERED STRUCTURES IN AN EXPERIMENT
Original languageRussian
Pages (from-to)201-208
JournalУРОЛОГИЧЕСКИЕ ВЕДОМОСТИ
Volume10
Issue number3
StatePublished - 2020

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