The DNA theory of inheritance in the scope of protein inheritance

Research output

Abstract

Statement of the Problem: It has long been accepted that any hereditary factor in any organism is represented by DNA sequences. This idea became fundamental in molecular genetics, and was implicitly transformed into the DNA theory of inheritance. All basic genetic terms (genotype, gene, allele, mutation, recombination, etc.) were considered as specific DNA sequences or their alterations. However, multiple examples of stable epigenetic inheritance lacking any distinctions in DNA sequences were recently discovered, and the most exciting among them is protein inheritance. Amyloid hereditary prions in fungi were considered as “protein-only” hereditary factors, which features were determined entirely by protein conformation. As a result, the principal question arises whether the DNA theory of inheritance is wrong or not. Methodology & Theoretical Orientation: Considering different variants of the same hereditary prion as prion alleles, we examined the molecular nature of such variety. Findings: To perpetuate stably in cell generations a certain prion allele requires two entities: specific state of the prion protein, and the corresponding DNA sequence to provide reproduction of the prion particles. We name these entities as the DNA determinant and the epigenetic determinant, respectively. Thus, a certain prion allele is a bimodular hereditary system depending on both the DNA determinant and the epigenetic determinant. Alteration of any of these two determinants may result in establishment of a novel prion allele. Moreover, similar regularities are characteristic to all other cases of epigenetic inheritance, irrespective to the underlying mechanisms. Conclusion & Significance: The hereditary role of DNA is fundamental for any known mechanisms of inheritance, including epigenetic. However, it becomes an element of a more complicated concept: in addition to “DNA-only” hereditary factors, various bimodular hereditary factors also exist.
Original languageEnglish
Title of host publication3rd International Conference on Molecular Biology & Nucleic Acids. August 27-28 2018, Toronto, Canada.
Subtitle of host publication3я Международная конференция по молекулярной биологии и нуклеиновым кислотам. 27-28 августа 2018, Торонто, Канада.
Pages41
Number of pages1
Publication statusPublished - 2018

Fingerprint

Prions
Epigenomics
DNA
Alleles
Proteins
Protein Conformation
Amyloid
Genetic Recombination
Names
Reproduction
Molecular Biology
Fungi
Genotype
Mutation
Genes

Cite this

Тиходеев, О. Н. (2018). The DNA theory of inheritance in the scope of protein inheritance. In 3rd International Conference on Molecular Biology & Nucleic Acids. August 27-28 2018, Toronto, Canada.: 3я Международная конференция по молекулярной биологии и нуклеиновым кислотам. 27-28 августа 2018, Торонто, Канада. (pp. 41)
Тиходеев, Олег Николаевич. / The DNA theory of inheritance in the scope of protein inheritance. 3rd International Conference on Molecular Biology & Nucleic Acids. August 27-28 2018, Toronto, Canada.: 3я Международная конференция по молекулярной биологии и нуклеиновым кислотам. 27-28 августа 2018, Торонто, Канада. . 2018. pp. 41
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abstract = "Statement of the Problem: It has long been accepted that any hereditary factor in any organism is represented by DNA sequences. This idea became fundamental in molecular genetics, and was implicitly transformed into the DNA theory of inheritance. All basic genetic terms (genotype, gene, allele, mutation, recombination, etc.) were considered as specific DNA sequences or their alterations. However, multiple examples of stable epigenetic inheritance lacking any distinctions in DNA sequences were recently discovered, and the most exciting among them is protein inheritance. Amyloid hereditary prions in fungi were considered as “protein-only” hereditary factors, which features were determined entirely by protein conformation. As a result, the principal question arises whether the DNA theory of inheritance is wrong or not. Methodology & Theoretical Orientation: Considering different variants of the same hereditary prion as prion alleles, we examined the molecular nature of such variety. Findings: To perpetuate stably in cell generations a certain prion allele requires two entities: specific state of the prion protein, and the corresponding DNA sequence to provide reproduction of the prion particles. We name these entities as the DNA determinant and the epigenetic determinant, respectively. Thus, a certain prion allele is a bimodular hereditary system depending on both the DNA determinant and the epigenetic determinant. Alteration of any of these two determinants may result in establishment of a novel prion allele. Moreover, similar regularities are characteristic to all other cases of epigenetic inheritance, irrespective to the underlying mechanisms. Conclusion & Significance: The hereditary role of DNA is fundamental for any known mechanisms of inheritance, including epigenetic. However, it becomes an element of a more complicated concept: in addition to “DNA-only” hereditary factors, various bimodular hereditary factors also exist.",
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Тиходеев, ОН 2018, The DNA theory of inheritance in the scope of protein inheritance. in 3rd International Conference on Molecular Biology & Nucleic Acids. August 27-28 2018, Toronto, Canada.: 3я Международная конференция по молекулярной биологии и нуклеиновым кислотам. 27-28 августа 2018, Торонто, Канада. . pp. 41.

The DNA theory of inheritance in the scope of protein inheritance. / Тиходеев, Олег Николаевич.

3rd International Conference on Molecular Biology & Nucleic Acids. August 27-28 2018, Toronto, Canada.: 3я Международная конференция по молекулярной биологии и нуклеиновым кислотам. 27-28 августа 2018, Торонто, Канада. . 2018. p. 41.

Research output

TY - GEN

T1 - The DNA theory of inheritance in the scope of protein inheritance

AU - Тиходеев, Олег Николаевич

PY - 2018

Y1 - 2018

N2 - Statement of the Problem: It has long been accepted that any hereditary factor in any organism is represented by DNA sequences. This idea became fundamental in molecular genetics, and was implicitly transformed into the DNA theory of inheritance. All basic genetic terms (genotype, gene, allele, mutation, recombination, etc.) were considered as specific DNA sequences or their alterations. However, multiple examples of stable epigenetic inheritance lacking any distinctions in DNA sequences were recently discovered, and the most exciting among them is protein inheritance. Amyloid hereditary prions in fungi were considered as “protein-only” hereditary factors, which features were determined entirely by protein conformation. As a result, the principal question arises whether the DNA theory of inheritance is wrong or not. Methodology & Theoretical Orientation: Considering different variants of the same hereditary prion as prion alleles, we examined the molecular nature of such variety. Findings: To perpetuate stably in cell generations a certain prion allele requires two entities: specific state of the prion protein, and the corresponding DNA sequence to provide reproduction of the prion particles. We name these entities as the DNA determinant and the epigenetic determinant, respectively. Thus, a certain prion allele is a bimodular hereditary system depending on both the DNA determinant and the epigenetic determinant. Alteration of any of these two determinants may result in establishment of a novel prion allele. Moreover, similar regularities are characteristic to all other cases of epigenetic inheritance, irrespective to the underlying mechanisms. Conclusion & Significance: The hereditary role of DNA is fundamental for any known mechanisms of inheritance, including epigenetic. However, it becomes an element of a more complicated concept: in addition to “DNA-only” hereditary factors, various bimodular hereditary factors also exist.

AB - Statement of the Problem: It has long been accepted that any hereditary factor in any organism is represented by DNA sequences. This idea became fundamental in molecular genetics, and was implicitly transformed into the DNA theory of inheritance. All basic genetic terms (genotype, gene, allele, mutation, recombination, etc.) were considered as specific DNA sequences or their alterations. However, multiple examples of stable epigenetic inheritance lacking any distinctions in DNA sequences were recently discovered, and the most exciting among them is protein inheritance. Amyloid hereditary prions in fungi were considered as “protein-only” hereditary factors, which features were determined entirely by protein conformation. As a result, the principal question arises whether the DNA theory of inheritance is wrong or not. Methodology & Theoretical Orientation: Considering different variants of the same hereditary prion as prion alleles, we examined the molecular nature of such variety. Findings: To perpetuate stably in cell generations a certain prion allele requires two entities: specific state of the prion protein, and the corresponding DNA sequence to provide reproduction of the prion particles. We name these entities as the DNA determinant and the epigenetic determinant, respectively. Thus, a certain prion allele is a bimodular hereditary system depending on both the DNA determinant and the epigenetic determinant. Alteration of any of these two determinants may result in establishment of a novel prion allele. Moreover, similar regularities are characteristic to all other cases of epigenetic inheritance, irrespective to the underlying mechanisms. Conclusion & Significance: The hereditary role of DNA is fundamental for any known mechanisms of inheritance, including epigenetic. However, it becomes an element of a more complicated concept: in addition to “DNA-only” hereditary factors, various bimodular hereditary factors also exist.

M3 - Conference contribution

SN - ISSN: 2168-9547

SP - 41

BT - 3rd International Conference on Molecular Biology & Nucleic Acids. August 27-28 2018, Toronto, Canada.

ER -

Тиходеев ОН. The DNA theory of inheritance in the scope of protein inheritance. In 3rd International Conference on Molecular Biology & Nucleic Acids. August 27-28 2018, Toronto, Canada.: 3я Международная конференция по молекулярной биологии и нуклеиновым кислотам. 27-28 августа 2018, Торонто, Канада. . 2018. p. 41