Влияние агониста TAAR5 α-NETA на поведение мышей линии C57BL/6

Translated title of the contribution: EFFECTS OF TAAR5 α-NETA AGONIST ON BEHAVIOR IN C57BL/6 MICE

Research output: Contribution to journalArticlepeer-review

Abstract

TAAR5 (trace amine-associated receptor 5) agonist systemic administration at a dose of 10 mg/kg induces a significant increase of anxiety and grooming duration 30 min after the drug administration compared with control animals. Locomotion and exploratory activities are significantly reduced. Locomotion, motor and exploratory behaviors come back to normal after 48 hours, while anxiety is still elevated. The agonist has not affected the social preference in the friend-foe test.
Translated title of the contributionEFFECTS OF TAAR5 α-NETA AGONIST ON BEHAVIOR IN C57BL/6 MICE
Original languageRussian
Pages (from-to)62-70
JournalЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА
Volume70
Issue number1
DOIs
StatePublished - 2020

Scopus subject areas

  • Neuroscience(all)

Keywords

  • TAAR5
  • α-NETA (2-(alpha-naph-thoyl)ethyltrimethylammonium iodide)
  • Trace amines
  • ANXIETY
  • SOCIAL BEHAVIOR
  • locomotion

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