БИОДЕГРАДИРУЕМЫЕ НАНОЧАСТИЦЫ НА ОСНОВЕ АЛИФАТИЧЕСКИХ СЛОЖНЫХ ПОЛИЭФИРОВ В КАЧЕСТВЕ СИСТЕМ ДОСТАВКИ ЛЕКАРСТВ

Translated title of the contribution: BIODEGRADABLE NANOPARTICLES BASED ON ALIPHATIC POLYESTER AS DRUG DELIVERY SYSTEM

Research output: Contribution to journalArticlepeer-review

Abstract

The preparation of nanocontainers for targeted drug delivery is a rapidly developing field of biomedical chemistry. The synthesis of biodegradable block copolymer of polyethylene glycol (PEG-5000) with polylactic acid (PLA) was performed via stannous octoate initiated ring-opening polymerization in bulk. Molecular weights and molecular weight distribution of obtained polymer were studied by Size exclusion chromatography (SEC). For the characterization of obtained samples 1H-NMR was used. Polymer particles with the sizes from 40 to 200 nm were prepared by nanoprecipitation method. Dioxadet was encapsulated in biodegradable polymer containers this cytotoxic drug used for the treatment of ovarian cancer. The encapsulation efficiency for the developed systems ranged from 46 to 83%, the loading content was equal to 230 μg mg-1 of particles.
Translated title of the contributionBIODEGRADABLE NANOPARTICLES BASED ON ALIPHATIC POLYESTER AS DRUG DELIVERY SYSTEM
Original languageRussian
Pages (from-to)622-625
JournalАКТУАЛЬНЫЕ ВОПРОСЫ БИОЛОГИЧЕСКОЙ ФИЗИКИ И ХИМИИ
Volume3
Issue number3
StatePublished - 2018

Keywords

  • BIODEGRADABLE PARTICLES
  • DRUG DELIVERY
  • NANOPRECIPITATION

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