АУТОИММУННАЯ ПРИРОДА САРКОИДОЗА: ОПРЕДЕЛЕНИЕ СПЕЦИФИЧЕСКИХ ИММУННЫХ КОМПЛЕКСОВ У БОЛЬНЫХ САРКОИДОЗОМ ОРГАНОВ ДЫХАНИЯ

Yu S. Zinchenko, A. A. Starshinova, M. V. Filatov, N. V. Denisova, S. B. Landa, V. S. Burdakov, P. K. Yablonskiy

Research output

Abstract

The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease. The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05. Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01). The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.

Original languageRussian
Pages (from-to)479-486
Number of pages8
JournalMedical Immunology (Russia)
Volume21
Issue number3
DOIs
Publication statusPublished - 2019

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Sarcoidosis
Antigen-Antibody Complex
Tissue Extracts
Lung
Tuberculosis
Antigens
Tissue Donors
Control Groups
Bacteria
spleen fibrinolytic proteinase (human)

Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

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title = "АУТОИММУННАЯ ПРИРОДА САРКОИДОЗА: ОПРЕДЕЛЕНИЕ СПЕЦИФИЧЕСКИХ ИММУННЫХ КОМПЛЕКСОВ У БОЛЬНЫХ САРКОИДОЗОМ ОРГАНОВ ДЫХАНИЯ",
abstract = "The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease. The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05. Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01). The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.",
keywords = "Autoimmunity, Dynamic light scattering method, Sarcoidosis, Specific immune complexes",
author = "Zinchenko, {Yu S.} and Starshinova, {A. A.} and Filatov, {M. V.} and Denisova, {N. V.} and Landa, {S. B.} and Burdakov, {V. S.} and Yablonskiy, {P. K.}",
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T1 - АУТОИММУННАЯ ПРИРОДА САРКОИДОЗА

T2 - ОПРЕДЕЛЕНИЕ СПЕЦИФИЧЕСКИХ ИММУННЫХ КОМПЛЕКСОВ У БОЛЬНЫХ САРКОИДОЗОМ ОРГАНОВ ДЫХАНИЯ

AU - Zinchenko, Yu S.

AU - Starshinova, A. A.

AU - Filatov, M. V.

AU - Denisova, N. V.

AU - Landa, S. B.

AU - Burdakov, V. S.

AU - Yablonskiy, P. K.

PY - 2019

Y1 - 2019

N2 - The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease. The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05. Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01). The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.

AB - The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease. The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05. Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01). The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.

KW - Autoimmunity

KW - Dynamic light scattering method

KW - Sarcoidosis

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