Abstract
The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease. The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05. Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01). The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.
| Original language | Russian |
|---|---|
| Pages (from-to) | 479-486 |
| Number of pages | 8 |
| Journal | Medical Immunology (Russia) |
| Volume | 21 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2019 |
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Scopus subject areas
- Immunology and Allergy
- Immunology
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АУТОИММУННАЯ ПРИРОДА САРКОИДОЗА : ОПРЕДЕЛЕНИЕ СПЕЦИФИЧЕСКИХ ИММУННЫХ КОМПЛЕКСОВ У БОЛЬНЫХ САРКОИДОЗОМ ОРГАНОВ ДЫХАНИЯ. / Zinchenko, Yu S.; Starshinova, A. A.; Filatov, M. V.; Denisova, N. V.; Landa, S. B.; Burdakov, V. S.; Yablonskiy, P. K.
In: Medical Immunology (Russia), Vol. 21, No. 3, 2019, p. 479-486.Research output
TY - JOUR
T1 - АУТОИММУННАЯ ПРИРОДА САРКОИДОЗА
T2 - ОПРЕДЕЛЕНИЕ СПЕЦИФИЧЕСКИХ ИММУННЫХ КОМПЛЕКСОВ У БОЛЬНЫХ САРКОИДОЗОМ ОРГАНОВ ДЫХАНИЯ
AU - Zinchenko, Yu S.
AU - Starshinova, A. A.
AU - Filatov, M. V.
AU - Denisova, N. V.
AU - Landa, S. B.
AU - Burdakov, V. S.
AU - Yablonskiy, P. K.
PY - 2019
Y1 - 2019
N2 - The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease. The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05. Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01). The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.
AB - The etiology of sarcoidosis is not completely understood. A hypothesis exists about the relationship between sarcoidosis and a complex of pathological autoimmune reactions that occur under the influence of triggering factors. In this study, specific immune complexes in the blood plasma of patients have been determined, which can indirectly reveal the causes of the disease. The study included 33 patients with lung sarcoidosis (I group), compared to 24 healthy donors who served as a control group (II group). The patients underwent standard examination. Their blood plasma was investigated by the dynamic light scattering method with addition of tuberculosis antigens (ESAT-6/SFP-10) and “lung healthy tissue extract”. Statistical analysis was performed using the Statistica 7.0 program. Test results were considered significant at p < 0.05. Аccording to the data obtained, addition of ESAT-6/SFP-10 to patient’s blood plasma almost did not lead to the formation of immune complexes in most samples. Meanwhile, development of such complexes after addition of “lung tissue extract” was revealed in all the patients. The immune complexes were not detected in any donor from control group after stimulation with both kinds of antigens (p < 0.01). The data on distinct formation of immune complexes with the addition of “lung healthy tissue extract” in patients with lung sarcoidosis may be considered an indirect evidence for occurrence of autoimmune reaction under the influence of some pathogenic factors. Absence of de novo immune complex formation after addition of tuberculosis antigens (ESAT-6/SFP-10) makes it unlikely any direct effects of tuberculosis bacteria upon development of sarcoidosis.
KW - Autoimmunity
KW - Dynamic light scattering method
KW - Sarcoidosis
KW - Specific immune complexes
UR - http://www.scopus.com/inward/record.url?scp=85070191457&partnerID=8YFLogxK
U2 - 10.15789/1563-0625-2019-3-479-486
DO - 10.15789/1563-0625-2019-3-479-486
M3 - статья
AN - SCOPUS:85070191457
VL - 21
SP - 479
EP - 486
JO - Medical Immunology (Russia)
JF - Medical Immunology (Russia)
SN - 1563-0625
IS - 3
ER -