АВИРЕМИЧЕСКАЯ НИЗКОУРОВНЕВАЯ РЕПЛИКАЦИЯ RNA HCV В ИММУННЫХ КЛЕТКАХ КРОВИ PBMC/WBC (ВТОРИЧНАЯ ОККУЛЬТНАЯ HCV-ИНФЕКЦИЯ) КАК ОДИН ИЗ РЕЗУЛЬТАТОВ ПЕРВИЧНОЙ БЕЗИНТЕРФЕРОНОВОЙ DAA-ТЕРАПИИ В РЕАЛЬНОЙ КЛИНИЧЕСКОЙ ПРАКТИКЕ У ПВТ-НАИВНЫХ ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ ВИРЕМИЕЙ RNA HCV (ОПИСАНИЕ СЕРИИ СЛУЧАЕВ)

Translated title of the contribution: Low-level aviremic hepatitis C virus (HCV) RNA replication in the immune blood PBMCs/WBCs (secondary occult HCV infectioi as one of the primary interferon-free DAA therapy outcomes in real clinical practice in antiviral therapy-naive patients with chronic HCV RNA viremia (a description of a series of cases)

А.А. Яковлев, Д. Сулима, В. Ларионов, В. Корягин , М. Шарипова , И. Федуняк, В. Мусатов, Г. Каченя, Е. Догужиева , О. Соколова, О. Горчакова, А. Семенов, Е. Зуева, Ю. Останкова, С. Просверницын, С. Кияшко, Ю. Чорногуз, Д. Валутите

Research output: Contribution to journalArticlepeer-review

Abstract

The paper presents the results of the authors’ own pilot study of the prevalence of secondary occult hepatitis C virus (HCV) infection after various primary interferon-free (direct-acting antivirals (DAA)) therapy regimens with original inhibitor drugs in real clinical practice. Examinations have been made in 27 patients randomly selected from 261 ones who achieved a traditional plasma sustained virological response at 12 weeks after the end of a DAA therapy cycle confirmed by HCV RNA aviremia.
Translated title of the contributionLow-level aviremic hepatitis C virus (HCV) RNA replication in the immune blood PBMCs/WBCs (secondary occult HCV infectioi as one of the primary interferon-free DAA therapy outcomes in real clinical practice in antiviral therapy-naive patients with chronic HCV RNA viremia (a description of a series of cases)
Original languageRussian
Pages (from-to)57-64
Number of pages13
JournalВРАЧ
Volume31
Issue number2
StatePublished - 2020

Keywords

  • HEPATOLOGY
  • SECONDARY OCCULT HCV INFECTION
  • SECONDARY OCCULT HEPATITIS C,
  • INTERFERON-FREE DAA THERAPY
  • IMMUNE BLOOD PBMCS/WBCS
  • PERIPHERAL MONONUCLEAR CELLS
  • CHRONIC HCV RNA VIREMIA
  • HCV RNA REPLICATION IN PBMCS/WBCS

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